A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective
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چکیده
منابع مشابه
A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective
BACKGROUND Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is known about its role in atherosclerosis. METHODS We tested the hypothesis that DKK3 is atheroprotective using both epidemiological and experimental approaches. Blood DKK3 levels were measured in the Bruneck S...
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Dickkopf-related protein 3 (Dkk-3) is a potential tumor suppressor reported in various cancer entities. However, we found that Dkk-3 was exceptionally upregulated in bladder cancer T24 cells. To validate the biological role of Dkk-3 other than a tumor suppressor, we examined the function of Dkk-3 in T24 cells. Gene silencing of Dkk-3 inhibited cell growth through inducing G₀/G₁ cell-cycle arres...
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ژورنال
عنوان ژورنال: Circulation
سال: 2017
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.117.027690